In the menu's Realtime Scanning appeared as Active. From the main screen I tried to enable Realtime Scanning and it seemed to start but the warning sign at the left column of the main screen remained. On my laptop a notification popup did appear to warn that Realtime Scanning was disabled. On my laptop the notification menu of McAfee stated the last update was on 20:08 (GMT+2) and on my PC on 22:03 (GMT+2).
I had exactly the same issue since about 22:30 (GMT+2) on both my laptop and after a restart of a PC (appearantly did hang after a restart after a powerloss) on that PC too.